Santa Cruz Vacation Packages

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Your Santa Cruz Vacation

With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.

Ready to book your vacation to Santa Cruz?

 

Choose your dates

Santa Cruz Hotel Deals

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
The price is CA $210 per night from Aug 12 to Aug 13
CA $210
CA $210 total
Aug 12 - Aug 13
8.8/10 Excellent! (394 reviews)
Best amenities
"Best amenities in a hotel , but need some upgrades"

Reviewed on Jul. 16, 2025

Camino Real Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
The price is CA $180 per night from Aug 25 to Aug 26
CA $180
CA $180 total
Aug 25 - Aug 26
8.8/10 Excellent! (321 reviews)
"Always an amazing hotel"

Reviewed on Jun. 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E, Santa Cruz
The price is CA $103 per night from Aug 15 to Aug 16
CA $103
CA $103 total
Aug 15 - Aug 16
9/10 Wonderful! (245 reviews)
"Location, surrounding, quietness, good service"

Reviewed on Jul. 7, 2025

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
See all 272 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre showing heritage architecture and heritage elements as well as a large group of people

Plaza 24 de Septiembre

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre

Ventura Mall

During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.

Ventura Mall

Guembe Biocenter

Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.

Guembe Biocenter

What to do in Santa Cruz

The Che Guevara route is the most peculiar tourist destination in Bolivia.

4D/3N Tour on the Che Guevara Route

CA $670
per adult
4D/3N Tour on the Che Guevara Route
See all activities in Santa Cruz

Frequently asked questions

How much does a Santa Cruz vacation package cost?
Offering excellent value package deals on Expedia, you'll be surprised at how little a vacation to Santa Cruz costs! Our packages mean less travel planning for you and greater savings.
What are the cheapest months to go to Santa Cruz?
If you're hoping to score a cheap Santa Cruz vacation package, consider planning a trip in February, April and May. You're likely to find lower prices on accommodations and flights during these months — ideal for travellers wishing to save money.
How many days is enough for Santa Cruz?
With a well-organized travel plan, you can easily tick off the most popular Santa Cruz attractions in a handful of days. But if you'd like to discover hidden spots or go on day trips, think about booking your Santa Cruz vacation for longer.
Is it worth booking a vacation package to Santa Cruz?
Santa Cruz is a good vacation destination with attractions like Ventura Mall among the many things to keep you busy. Whether you're travelling with the family or planning a trip with friends, a Santa Cruz vacation promises fun for everyone.
How to find the best Santa Cruz package deals?
Begin your search for a Santa Cruz package deal by entering your destination and preferred travel dates under our "Packages" tab. Then apply a few filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Santa Cruz package deal right away, simply play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Cruz adventure off to a flying start.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Santa Cruz vacation by choosing your favourite type of stay, airline and car class.
When to book a vacation package to Santa Cruz?
If you're planning a spontaneous Santa Cruz getaway, browse our last-minute deals that can be booked up to a week before you go. Don't want to leave things to the last minute? You can find terrific deals on your flights and hotels by booking ahead.
How to plan a trip to Santa Cruz?

  1. Choose your dates: What you'd like to do in Santa Cruz and your preferred season can help you decide when to travel.
  2. Figure out your budget: Ensure you have enough money to pay for everything from food and transportation to activities and airfares. Your hotel will likely be the largest expense during your trip to Santa Cruz.
  3. Decide your trip length: Think about how long you'd like to spend discovering Santa Cruz. Plan your itinerary so you can get to all the experiences and attractions you're interested in at a leisurely pace.
  4. Combine your accommodations and airfare: Once you've settled on your travel dates and duration, book the right Santa Cruz vacation package for you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.